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AC710

Catalog No. TQ0235Cas No. 1351522-04-7

AC710 is a potent PDGFR inhibitor with Kds of 0.6 nM for FLT3, 1 nM for KIT, 1.57 nM for CSF1R, 1.3 nM for PDGFRα, and 1 nM for PDGFRβ.

AC710

AC710

Purity: 99.48%
Catalog No. TQ0235Cas No. 1351522-04-7
AC710 is a potent PDGFR inhibitor with Kds of 0.6 nM for FLT3, 1 nM for KIT, 1.57 nM for CSF1R, 1.3 nM for PDGFRα, and 1 nM for PDGFRβ.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$38In Stock
5 mg$63In Stock
10 mg$98In Stock
25 mg$198In Stock
50 mg$297In Stock
100 mg$448In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Purity:99.48%
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Product Introduction

Bioactivity
Description
AC710 is a potent PDGFR inhibitor with Kds of 0.6 nM for FLT3, 1 nM for KIT, 1.57 nM for CSF1R, 1.3 nM for PDGFRα, and 1 nM for PDGFRβ.
Targets&IC50
c-Kit:1 nM (Kd), FLT3:0.6 nM (Kd), PDGFRβ:1 nM (Kd), CSF1R:1.57 nM (Kd), PDGFRα:1.3 nM (Kd)
In vivo
At a dosage of 0.3 mg/kg, AC710 transiently inhibits tumor growth, with rapid resumption following cessation. Doses of 3 and 30 mg/kg result in complete tumor regression and prolonged suppression of tumor volume post-treatment. Notably, administration of AC710 does not lead to bodyweight loss in treated animals across all tested doses. Further, AC710 significantly mitigates disease progression in a mouse collagen-induced arthritis (CIA) model in a dose-dependent manner, starting from a low dose of 3 mg/kg over a span of 15 days (day 0-14). At increased dosages of 10 and 30 mg/kg, AC710's effectiveness in reducing joint swelling and inflammation is comparable or slightly superior to that of dexomethasone administered at a safe dose.
Animal Research
The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.
Chemical Properties
Molecular Weight562.7
FormulaC31H42N6O4
Cas No.1351522-04-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 15 mg/mL (26.66 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7771 mL8.8857 mL17.7715 mL88.8573 mL
5 mM0.3554 mL1.7771 mL3.5543 mL17.7715 mL
10 mM0.1777 mL0.8886 mL1.7771 mL8.8857 mL
20 mM0.0889 mL0.4443 mL0.8886 mL4.4429 mL

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