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AC710

Catalog No. TQ0235 CAS 1351522-04-7

AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AC710, CAS 1351522-04-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 57.00
2 mg	In stock	$ 82.00
5 mg	In stock	$ 137.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 515.00
100 mg	In stock	$ 747.00
1 mL * 10 mM (in DMSO)	In stock	$ 168.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
Targets&IC50	FLT3:0.6 nM (Kd), c-Kit:1 nM (Kd), PDGFRβ:1 nM (Kd), PDGFRα:1.3 nM (Kd), CSF1R:1.57 nM (Kd)
In vivo	At a dosage of 0.3 mg/kg, AC710 transiently inhibits tumor growth, with rapid resumption following cessation. Doses of 3 and 30 mg/kg result in complete tumor regression and prolonged suppression of tumor volume post-treatment. Notably, administration of AC710 does not lead to bodyweight loss in treated animals across all tested doses. Further, AC710 significantly mitigates disease progression in a mouse collagen-induced arthritis (CIA) model in a dose-dependent manner, starting from a low dose of 3 mg/kg over a span of 15 days (day 0-14). At increased dosages of 10 and 30 mg/kg, AC710's effectiveness in reducing joint swelling and inflammation is comparable or slightly superior to that of dexomethasone administered at a safe dose.
Animal Research	The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight are monitored.

Molecular Weight	562.7
Formula	C31H42N6O4
CAS No.	1351522-04-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (26.66 mM), Sonication and heating are recommended.

References and Literature

1. Liu G, et al. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med Chem Lett. 2012 Sep 24;3(12):997-1002.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Covalent Inhibitor Library Bioactive Compound Library Angiogenesis related Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AC710 1351522-04-7 Angiogenesis Tyrosine Kinase/Adaptors FLT PDGFR c-Kit Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 CD117 Platelet-derived growth factor receptor CD135 Inhibitor AC 710 AC-710 FLT3 SCFR inhibit inhibitor

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