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AGI-14100

Catalog No. T25006Cas No. 1448346-43-7
Alias AGI 14100

AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.

AGI-14100

AGI-14100

Purity: 100%
Catalog No. T25006Alias AGI 14100Cas No. 1448346-43-7
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
Pack SizePriceAvailabilityQuantity
1 mg$350In Stock
5 mg$828In Stock
10 mg$1,130In Stock
25 mg$1,590In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
Targets&IC50
IDH1-R132H homodimer (mutation):6 nM, HT1080 (chondrosarcoma cell lines):1 nM
In vivo
AGI-14100 (50 mg/kg; oral; single; female nude BALB/c mice) inhibition robust tumor 2-HG was achieved 12 hours post-dose demonstrating desirable in vivo results.[1]
AGI-14100 had decent oral pharmacokinetics (PK) properties in rats (F =44 %), dogs (F =18 %), and cynomolgus monkeys (F =43 %).[1]
AliasAGI 14100
Chemical Properties
Molecular Weight599.96
FormulaC29H22ClF4N5O3
Cas No.1448346-43-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (83.34 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6668 mL8.3339 mL16.6678 mL83.3389 mL
5 mM0.3334 mL1.6668 mL3.3336 mL16.6678 mL
10 mM0.1667 mL0.8334 mL1.6668 mL8.3339 mL
20 mM0.0833 mL0.4167 mL0.8334 mL4.1669 mL
50 mM0.0333 mL0.1667 mL0.3334 mL1.6668 mL

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