Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 107.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 362.00 | |
25 mg | In stock | $ 610.00 | |
50 mg | In stock | $ 868.00 | |
100 mg | In stock | $ 1,190.00 | |
500 mg | In stock | $ 2,390.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 287.00 |
Description | AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity. |
Targets&IC50 | p38β:82 nM, p38α:6 nM |
In vivo | In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw[1]. |
Molecular Weight | 402.41 |
Formula | C21H21F3N4O |
CAS No. | 1057394-06-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (236.08 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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AL 8697 1057394-06-5 MAPK p38 MAPK inhibit AL8697 AL-8697 Autophagy Inhibitor inhibitor