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AL 8697

Catalog No. T10277   CAS 1057394-06-5

AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.

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AL 8697 Chemical Structure
AL 8697, CAS 1057394-06-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 107.00
5 mg In stock $ 247.00
10 mg In stock $ 362.00
25 mg In stock $ 610.00
50 mg In stock $ 868.00
100 mg In stock $ 1,190.00
500 mg In stock $ 2,390.00
1 mL * 10 mM (in DMSO) In stock $ 287.00
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Purity: 99.26%
Purity: 98.96%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.
Targets&IC50 p38β:82 nM, p38α:6 nM
In vivo In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw[1].
Molecular Weight 402.41
Formula C21H21F3N4O
CAS No. 1057394-06-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (236.08 mM), sonification is recommended.

TargetMolReferences and Literature

1. Balagué C, et al. Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br J Pharmacol. 2012 Jun;166(4):1320-32.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Anti-Obesity Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Kinase Inhibitor Library Orally Active Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Pyroptosis Compound Library

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Keywords

AL 8697 1057394-06-5 MAPK p38 MAPK inhibit AL8697 AL-8697 Autophagy Inhibitor inhibitor

 

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