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ALK-IN-1

Catalog No. T3059Cas No. 1197958-12-5
Alias Brigatinib, AP26113-analog, AP26113

ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.

ALK-IN-1

ALK-IN-1

Purity: 100%
Catalog No. T3059Alias Brigatinib, AP26113-analog, AP26113Cas No. 1197958-12-5
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$64In Stock
25 mg$97In Stock
50 mg$147In Stock
100 mg$247In Stock
200 mg$367In Stock
500 mg$595In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
Targets&IC50
ALK:0.62 nM
Cell Research
Three-day cell viability assays are carried out by plating 2,000, 1,500 and 2,000 cells per well of Ba/F3, PC9 or MGH121, respectively, into black transparent-bottom 96-well plates. On the same day for Ba/F3 cells and the following day for PC9 and MGH121 cells, the cells are treated with each TKI across a 10-dose range from 0.3 nM to 10 μM. After 72 h of drug treatment, cell viability is measured using the CellTiter-Glo assay. (Only for Reference)
AliasBrigatinib, AP26113-analog, AP26113
Chemical Properties
Molecular Weight529.01
FormulaC26H34ClN6O2P
Cas No.1197958-12-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 98 mg/mL (185.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 1 mg/mL, Sonication is recommended.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM1.8903 mL9.4516 mL18.9032 mL94.5162 mL
5 mM0.3781 mL1.8903 mL3.7806 mL18.9032 mL
10 mM0.1890 mL0.9452 mL1.8903 mL9.4516 mL
20 mM0.0945 mL0.4726 mL0.9452 mL4.7258 mL
50 mM0.0378 mL0.1890 mL0.3781 mL1.8903 mL
100 mM0.0189 mL0.0945 mL0.1890 mL0.9452 mL

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