store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 nM) and B-Raf (IC50 <1000 nM), respectively.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | 6-8 weeks | Inquiry | |
50 mg | 6-8 weeks | Inquiry | |
100 mg | 6-8 weeks | Inquiry |
Description | AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM), respectively. |
Targets&IC50 | PERK:6 nM |
In vitro | AMG PERK 44 shows an inhibitory for cell pPERK (IC50: 84 nM ) [1]. |
In vivo | AMG PERK 44 (orally; 3-100 mg/kg) robustly inhibits PERK autophosphorylation (ED50: 3 mg/kg; ED90: 60 mg/kg at the 4 hours time point), and >50% target coverage is maintained for 24 h in a time course PD assay when dosed at 100 mg/kg p.o. AMG PERK 44 (iv; 1 mg/kg) has a CL of 1.6 L/h?kg, a Vss of 3.6 L/kg, and MRT of 2.3 hours in Sprague-Dawley rats and male CD-1 mice [1]. |
Molecular Weight | 561.07 |
Formula | C34H29ClN4O2 |
CAS No. | 1883548-84-2 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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AMG PERK 44 1883548-84-2 MAPK ERK inhibitor inhibit