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AX-15836

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Purity:99.03%

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COA HPLC HNMR

AX-15836

Catalog No. T14360Cas No. 2035509-96-5

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

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Pack Size	Price	Availability
1 mg	$52	In Stock
2 mg	$74	In Stock
5 mg	$123	In Stock
10 mg	$179	In Stock
25 mg	$313	In Stock
50 mg	$446	In Stock
100 mg	$629	In Stock
500 mg	$1,290	In Stock
1 mL x 10 mM (in DMSO)	$176	In Stock

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Product Introduction

Bioactivity

Description

AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

In vitro

AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases and it also shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells[1].

Chemical Properties

Molecular Weight	648.78
Formula	C32H40N8O5S
Cas No.	2035509-96-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (154.14 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5414 mL	7.7068 mL	15.4135 mL	77.0677 mL
5 mM	0.3083 mL	1.5414 mL	3.0827 mL	15.4135 mL
10 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7068 mL
20 mM	0.0771 mL	0.3853 mL	0.7707 mL	3.8534 mL
50 mM	0.0308 mL	0.1541 mL	0.3083 mL	1.5414 mL
100 mM	0.0154 mL	0.0771 mL	0.1541 mL	0.7707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc