Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 73.00 | |
2 mg | In stock | $ 107.00 | |
5 mg | In stock | $ 187.00 | |
10 mg | In stock | $ 276.00 | |
25 mg | In stock | $ 567.00 | |
50 mg | In stock | $ 813.00 | |
100 mg | In stock | $ 1,130.00 | |
500 mg | In stock | $ 2,260.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 268.00 |
Description | AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM). |
Targets&IC50 | ERK5:8 nM |
In vitro | AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases and it also shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells[1]. |
Molecular Weight | 648.78 |
Formula | C32H40N8O5S |
CAS No. | 2035509-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (154.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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AX-15836 2035509-96-5 MAPK ERK Extracellular signal regulated kinases AX 15836 inhibit AX15836 Inhibitor inhibitor