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AZ1495

Catalog No. T14367   CAS 2196204-23-4

AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).

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AZ1495 Chemical Structure
AZ1495, CAS 2196204-23-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 148.00
5 mg In stock $ 278.00
10 mg In stock $ 455.00
25 mg In stock $ 647.00
50 mg In stock $ 913.00
100 mg In stock $ 1,390.00
1 mL * 10 mM (in DMSO) In stock $ 313.00
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Purity: 98.36%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).
Targets&IC50 CLK1:50 nM, CLK2:5 nM, IRAK4:5 nM, CLK4:8 nM, Haspin:4 nM, IRAK1:23 nM
Molecular Weight 385.5
Formula C21H31N5O2
CAS No. 2196204-23-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (25.94 mM), sonification is recommended.

TargetMolReferences and Literature

1. Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.

Related compound libraries

This product is contained In the following compound libraries:
Immunology/Inflammation Compound Library Cell Cycle Compound Library NF-κB Signaling Compound Library Kinase Inhibitor Library Anti-Prostate Cancer Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max

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Keywords

AZ1495 2196204-23-4 Cell Cycle/Checkpoint Immunology/Inflammation NF-Κb IRAK CDK Haspin Kinase Interleukin-1 receptor associated kinase interleukin-1 receptor associated kinase 4 (IRAK4) inhibit AZ 1495 cancer IL-1R associated kinase weak base diffuse large B-cell lymphoma (DLBCL) Inhibitor interleukin-1 receptor associated kinase 1 (IRAK1) AZ-1495 inhibitor

 

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