Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 61.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 243.00 | |
50 mg | In stock | $ 428.00 | |
100 mg | In stock | $ 635.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 78.00 |
Description | AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM). |
Targets&IC50 | PAR-2:23 nM(kd) |
In vitro | AZ3451 is selective for PAR2 over PAR4 and PAR1 (IC50s = <2.5, 380, and >50,000 nM, respectively, in a β-arrestin-2 recruitment assay). AZ3541 completely inhibits SLIGRL-induced phosphorylation of ERK in 1321N1 astrocytoma cells when used at a concentration of 10 μM. |
Molecular Weight | 571.46 |
Formula | C30H27BrN4O3 |
CAS No. | 2100284-59-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 80 mg/mL (140 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZ3451 2100284-59-9 GPCR/G Protein Protease-activated Receptor inhibit Protease Activated Receptor (PAR) AZ-3451 AZ 3451 Thrombin receptors Inhibitor inhibitor