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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $213 | In Stock | |
2 mg | $318 | In Stock | |
5 mg | $538 | In Stock | |
10 mg | $778 | In Stock | |
25 mg | $1,180 | In Stock | |
50 mg | $1,620 | In Stock | |
100 mg | $2,180 | In Stock | |
1 mL x 10 mM (in DMSO) | $593 | In Stock |
Description | AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis. |
In vitro | In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1]. |
In vivo | AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3]. |
Alias | AZD 5672, AZD5672, UNII-61XQN688TW |
Molecular Weight | 632.78 |
Formula | C32H38F2N2O5S2 |
Cas No. | 780750-65-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (47.4 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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