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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $62 | In Stock | |
5 mg | $148 | In Stock | |
10 mg | $239 | In Stock | |
25 mg | $433 | In Stock | |
50 mg | $638 | In Stock | |
100 mg | $892 | In Stock | |
1 mL x 10 mM (in DMSO) | $167 | In Stock |
Description | AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. It demonstrates potent single-digit nM growth inhibition across a broad cell panel. |
In vivo | Following a single dose (AZD3229, 20 mg/kg), high free cover over the target is achieved and is associated with complete suppression of pKIT and downstream markers out to 8 hours. As the compound is cleared and cover declines, these signals recover although recovery is not complete even at 24 hours. |
Molecular Weight | 479.51 |
Formula | C24H26FN7O3 |
Cas No. | 2248003-60-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 95 mg/mL (198.12 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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