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Alexidine dihydrochloride

Catalog No. T14177   CAS 1715-30-6

Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Thus, Alexidine dihydrochloride has the potential to be developed as a pan-antifungal, antibiofilm drug.

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Alexidine dihydrochloride Chemical Structure
Alexidine dihydrochloride, CAS 1715-30-6
Pack Size Availability Price/USD Quantity
25 mg In stock $ 54.00
50 mg In stock $ 72.00
100 mg In stock $ 101.00
1 mL * 10 mM (in DMSO) In stock $ 32.00
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Purity: 98.31%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Thus, Alexidine dihydrochloride has the potential to be developed as a pan-antifungal, antibiofilm drug.
In vitro Alexidine dihydrochloride can decimate at low concentrations (1.5 to 6 μg/mL) mature biofilms of Candida, Cryptococcus, and Aspergillus spp. that are known to be resistant to almost all classes of antifungal drugs. Alexidine dihydrochloride displays activity against most Candida spp.; MIC values of ≤1.5 μg/mL are observed for all isolates tested under planktonic conditions, with the exception of Candida parapsilosis and Candida krusei and it also displays striking activity against clinically relevant fluconazole-resistant Candida isolates: C. albicans (CA2, CA6, and CA10), C. glabrata (CG2 and CG5), C. parapsilosis (CP5), and C. auris (CAU-09 and CAU-03)[1]. Inhibition of planktonic growth by Alexidine dihydrochloride reveals a complete inhibition of filamentation or proliferation of the imaged fungi. Alexidine dihydrochloride results in 50% killing of HUVECs and lung epithelial cells, at concentrations 5- to 10-fold higher than the MIC required to kill planktonically growing fungal pathogens[1]. In fact, at 10-fold-lower concentrations (150 ng/mL) of planktonic MICs, Alexidine dihydrochloride could inhibit lateral yeast formation and biofilm dispersal in C. albicans[1].
In vivo Biofilm formation by C. Albicans is chosen to focus on because a murine biofilm model has been well established in this fungus and used for testing the effects of established and new antifungal agents. In fact, fungal CFU determination reveals that Alexidine dihydrochloride inhibits 67% of fungal biofilm growth and viability, compared to the control untreated biofilms[1]. The effect of the drugs on the 24-h-old biofilms growing in the jugular vein catheters of mice is visualized microscopically, which reveals significantly lower density of the biofilms in catheters treated with Alexidine dihydrochloride.
Molecular Weight 581.71
Formula C26H58Cl2N10
CAS No. 1715-30-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (429.77 mM), sonification is recommended.

TargetMolReferences and Literature

1. Mamouei Z, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 Oct 31;3(5). pii: e00539-18.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max NO PAINS Compound Library Anti-Infection Compound Library Apoptosis Compound Library Anti-Fungal Compound Library Bioactive Compound Library Mitochondria-Targeted Compound Library Anti-Cancer Compound Library Anti-Cancer Active Compound Library

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Keywords

Alexidine dihydrochloride 1715-30-6 Apoptosis Microbiology/Virology Others Antifungal anticancer antibiofilm Fungal mitochondrial AXD antifungal phosphatase Alexidine Dihydrochloride tyrosine inhibit PTPMT1 Alexidine Inhibitor inhibitor

 

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