Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 82.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 181.00 | |
50 mg | In stock | $ 265.00 | |
100 mg | In stock | $ 392.00 | |
500 mg | In stock | $ 933.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 88.00 |
Description | Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM. |
In vitro | Allopurinol riboside is effective against parasites including leishmaniasis and American trypanosomiasis. Allopurinol riboside is selectively toxic because it is not metabolized by the corresponding enzymes in humans[1]. Humoral immunity is not suppressed by Allopurinol riboside. Lymphocyte blastogenesis induced by PHA and Con A is significantly suppressed by Allopurinol riboside in a concentration-dependent manner[2]. |
In vivo | Low levels of Allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma[3]. Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 h, and has steady-state concentrations in the therapeutic range[4]. |
Molecular Weight | 268.23 |
Formula | C10H12N4O5 |
CAS No. | 16220-07-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (354.17 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Allopurinol riboside 16220-07-8 Metabolism Microbiology/Virology Others Drug Metabolite Endogenous Metabolite Parasite inhibit Inhibitor inhibitor