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AzddMeC
Catalog No. T26726Cas No. 87190-79-2
Alias CS-92, Azidodideoxymethylcytidine, Az-Dcme
AzddMeC (Az-Dcme) is a nucleoside analog with antiviral activity and is an orally active and selective inhibitor of HIV-1 reverse transcriptase and HIV-1 replication.AzddMeC has an EC50 value of 9 nM against HIV-1-infected human PBM cells and 6 nM against HIV-1-infected human macrophages.
AzddMeC
Purity: 99.62%
Catalog No. T26726Alias CS-92, Azidodideoxymethylcytidine, Az-DcmeCas No. 87190-79-2
AzddMeC (Az-Dcme) is a nucleoside analog with antiviral activity and is an orally active and selective inhibitor of HIV-1 reverse transcriptase and HIV-1 replication.AzddMeC has an EC50 value of 9 nM against HIV-1-infected human PBM cells and 6 nM against HIV-1-infected human macrophages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $71 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $278 | In Stock | |
| 25 mg | $562 | In Stock | |
| 50 mg | $892 | In Stock | |
| 100 mg | $1,490 | In Stock |
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CitedSelect Batch
Purity:99.62%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AzddMeC (Az-Dcme) is a nucleoside analog with antiviral activity and is an orally active and selective inhibitor of HIV-1 reverse transcriptase and HIV-1 replication.AzddMeC has an EC50 value of 9 nM against HIV-1-infected human PBM cells and 6 nM against HIV-1-infected human macrophages. |
| Targets&IC50 | HIV-1:9 nM (EC50, Human PBM cells), HIV-1:6 nM (EC50, Human macrophages) |
| In vitro | AzddMeC emerged as the most potent inhibitor of hepatitis B virus DNA polymerase (50% inhibitor dose, 0.03-0.35 μM). In contrast, cellular DNA polymerase was shown to be resistant to or partially (β) affected by AzddMeC. [4] |
| In vivo | Following intravenously and orally administered 60 mg/kg AzddMeC to male rhesus monkeys, 3'-azido-3'-deoxythymidine (AZT) was found to be the major metabolite of AzddMeC in monkeys. Serum concentrations of AzddMeC decreased rapidly in a biexponential manner with terminal half-lives ranging from 0.5 to 1.3 h. Total clearance of AzddMeC was 2.00 +/- 0.41 l/h/kg (mean +/- standard deviation) and the fraction of AzddMeC metabolized to AZT was 0.32 +/- 0.05. The total clearance was 2.00 +/- 0.41 l/h/kg (mean +/- standard deviation).[2] |
| Alias | CS-92, Azidodideoxymethylcytidine, Az-Dcme |
| Molecular Weight | 266.26 |
| Formula | C10H14N6O3 |
| Cas No. | 87190-79-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (375.57 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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