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BAM 15

Catalog No. T14497 CAS 210302-17-3

BAM 15 is an uncoupler of mitochondrial protonophore.

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BAM 15, CAS 210302-17-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 59.00
10 mg	In stock	$ 109.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 497.00
500 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 99.89%

Purity: 99.75%

Purity: 99.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BAM 15 is an uncoupler of mitochondrial protonophore.
In vitro	BAM 15 effectively enhances mitochondrial respiration and oxygen consumption across a wide concentration range without increasing reactive oxygen species (ROS), displaying a broader range of action compared to FCCP in myoblasts and hepatocytes. Despite structural differences from FCCP, BAM 15 at concentrations between 100 nM and 1 μM increases the cellular oxygen consumption rate (OCR) similarly to FCCP, but at higher concentrations (1 μM to 50 μM), it sustains uncoupled respiration more effectively across various cell lines. Additionally, BAM 15 causes mitochondrial swelling, indicating its role as a protonophore, and demonstrates greater cell viability than FCCP when used up to 50 μM[1].
In vivo	Animals that receive BAM 15 are protected from kidney injury compared to vehicle-treated mice, such as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less obstruction of proximal tubules, less depletion of brush border villi, and less immune cell infiltration[1].

Molecular Weight	340.29
Formula	C16H10F2N6O
CAS No.	210302-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (211.58 mM), Sonification is recommended.

References and Literature

1. Kenwood BM, et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2013 Nov 28;3(2):114-23.

Related compound libraries

This product is contained In the following compound libraries：

Metabolism Compound Library Cuproptosis Compound Library Bioactive Compounds Library Max Apoptosis Compound Library NO PAINS Compound Library Mitochondria-Targeted Compound Library Bioactive Compound Library Anti-Aging Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BAM 15 210302-17-3 Apoptosis Metabolism OXPHOS Mitochondrial Metabolism inhibit BAM15 BAM-15 Inhibitor inhibitor

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