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Cell Cycle/Checkpoint ROCK BDP5290

BDP5290

Catalog No. T7301   CAS 1817698-21-7
Purity 98.00% Datasheet

BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)

BDP5290, CAS 1817698-21-7
Pack Size Availability Price/USD Quantity
2 mg In stock 123.00
5 mg In stock 199.00
10 mg In stock 329.00
25 mg In stock 662.00
50 mg In stock 1193.00
100 mg In stock 2057.00
1 mL * 10 mM (in DMSO) In stock 164.00
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Purity 98.00%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
Targets&IC50 ROCK1 :ic50 5 nM,   ROCK2 :ic50 50 nM,   MRCKα :ic50 10 nM,   MRCKβ :ic50 100 nM,  
Cell Research
MDA MB 231 or SCC12 cells were plated in a 96 well plate and cultured for 24 hours. Cells were then cultured for 24 hours in SCC12 medium with DMSO vehicle, 2 μM Y27632 or indicated concentrations of BDP5290 in an IncuCyte ZOOM. Pictures were taken every 3 hours and confluence was measured using the IncuCyte analysis software. AlamarBlue was added to the medium and the cells were cultured for an additional day. Absorbances at 570 nm and at 600 nm were measured to assess cell health.
Synonyms
Purity 98.00%
Appearance solid
Molecular Weight 371.82
Formula C17H18ClN7O
CAS No. 1817698-21-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 12.5 mg/mL (33.62 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Unbekandt M , Croft D R , Crighton D , et al. A novel small-molecule MRCK inhibitor blocks cancer cell invasion[J]. Cell Communication and Signaling, 2014, 12(1):54. 2. Gandalovičová A, et al. Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. Trends Cancer. 2017 Jun;3(6):391-406.

Related Products

Related compounds with same targets
Y-27632 dihydrochloride RKI-1447 Capivasertib RKI-1313 Thiazovivin Tofacitinib Citrate AT13148 GSK429286A

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