Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 112.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 355.00 | |
25 mg | In stock | $ 590.00 | |
50 mg | In stock | $ 859.00 | |
100 mg | In stock | $ 1,180.00 |
Description | BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding. |
Molecular Weight | 287.74 |
Formula | C15H14ClN3O |
CAS No. | 4929-23-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.87 mg/mL (9.99 mM)
You can also refer to dose conversion for different animals. More
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BI-0115 4929-23-1 Metabolism Lipoxygenase BI 0115 inhibit LOX-1 BI0115 atherosclerosis oxLDL binding Inhibitor inhibitor