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BMS-986158

Catalog No. T14685 CAS 1800340-40-2

BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells.

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BMS-986158, CAS 1800340-40-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 79.00
5 mg	In stock	$ 272.00
10 mg	In stock	$ 490.00
25 mg	In stock	$ 785.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,460.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 98.77%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells.
Targets&IC50	BET:5 nM (in MDA-MB231 TNBC) cells), BET:6.6 nM(in NCI-H211 SCLC cells)
In vitro	BMS-986158 acts as an inhibitor targeting the bromodomain (BRD) and extra-terminal domain (BET) protein family, offering potential for cancer treatment. When administered, BMS-986158 attaches to the BRD's acetyl-lysine binding site on BET proteins, blocking their interaction with acetylated histones. This interruption hampers chromatin remodeling and curbs the expression of genes that promote growth, thereby inhibiting tumor cell proliferation[2].

Molecular Weight	495.62
Formula	C30H33N5O2
CAS No.	1800340-40-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (121.06 mM), Sonification is recommended

References and Literature

1. Yin M, et al. Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction. Nat Commun. 2020 Apr 14;11(1):1833.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Epigenetics Compound Library Anti-Lung Cancer Compound Library Bioactive Compound Library Clinical Compound Library PPI Inhibitor Library

Related Products

Related compounds with same targets

I-BET151 BAY-850 GSK778 hydrochloride DBr-1 ABBV-744 NI-57 Tz-Thalidomide BAZ1A-IN-1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-986158 1800340-40-2 Chromatin/Epigenetic Epigenetic Reader Domain BMS 986158 BMS986158 inhibit Inhibitor inhibitor

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