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BP-1-102

Catalog No. T3708Cas No. 1334493-07-0

BP-1-102 is an orally active, effective, and specific STAT3 inhibitor that binds Stat3 (Kd: 504 nM), blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhibits the migration, survival, growth, and invasion of Stat3-dependent tumor cells. The BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of [c-Myc, Bcl-xL, Cyclin D1, Survivin, and VEGF].

BP-1-102

BP-1-102

Purity: 99.81%
Catalog No. T3708Cas No. 1334493-07-0
BP-1-102 is an orally active, effective, and specific STAT3 inhibitor that binds Stat3 (Kd: 504 nM), blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhibits the migration, survival, growth, and invasion of Stat3-dependent tumor cells. The BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of [c-Myc, Bcl-xL, Cyclin D1, Survivin, and VEGF].
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
2 mg$47In Stock
5 mg$76In Stock
10 mg$122In Stock
25 mg$222In Stock
50 mg$372In Stock
100 mg$549In Stock
1 mL x 10 mM (in DMSO)$106In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
BP-1-102 is an orally active, effective, and specific STAT3 inhibitor that binds Stat3 (Kd: 504 nM), blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhibits the migration, survival, growth, and invasion of Stat3-dependent tumor cells. The BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of [c-Myc, Bcl-xL, Cyclin D1, Survivin, and VEGF].
Targets&IC50
STAT3:504 nM(Kd)
In vitro
BP-1-102 binds Stat3 with an affinity (KD) of 504 nM, inhibits Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM, and selectively inhibits the growth, survival, migration, and invasion of Stat3-dependent tumor cells. BP-1-102-mediated inhibition of aberrant Stat3 in tumor cells suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and Krüppel-like factor 8, a Stat3 target gene promoting breast tumor cell migration and invasion. Treatment of breast cancer cells with BP-1-102 also blocks Stat3–NF-κB cross-talk, the release of several cytokines, and the phosphorylation of focal adhesion kinase and paxillin, while enhancing E-cadherin expression. BP-1-102 inhibits Stat3 DNA-binding activity in vitro with an IC50 of 6.8±0.8 μM and preferentially inhibits Stat3-Stat3 over other Stat dimer DNA-binding activities. BP-1-102 exerts minimal or no effect on phospho-Shc, Src, Jak-1/2, Erk1/2, or Akt levels[1].
In vivo
Intravenous or oral gavage delivery of BP-1-102 furnishes micromolar or microgram levels in tumor tissues and inhibits growth of human breast and lung tumor xenografts and modulates Stat3 activity, Stat3 target genes, and soluble factors in vivo. BP-1-102 selectively suppresses growth, survival, malignant transformation, migration, and invasion of malignant cells harboring constitutively active stat3. BP-1-102 is detectable at micromolar concentrations in plasma and in micrograms in tumor tissues[1].
Kinase Assay
Kinase targets are tested with biochemical enzymatic kinase assays using the SelectScreen Kinase Profiling Service to determine IC50 values. The compounds (XMD8-87) are assayed at 10 concentrations (3-fold serial dilutions starting from 1 μM) at an ATP concentration equal to the ATP Km[1].
Cell Research
Proliferating cells in 6- or 96-well plates are treated once with 0–30 μM BP-1-102 for 24 h or with 10 μM BP-1-102 for up to 96 h. Viable cells are counted by trypan blue exclusion/phase-contrast microscopy or assessed by a CyQUANT Cell Proliferation Kit.(Only for Reference)
Chemical Properties
Molecular Weight626.59
FormulaC29H27F5N2O6S
Cas No.1334493-07-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (148.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5959 mL7.9797 mL15.9594 mL79.7970 mL
5 mM0.3192 mL1.5959 mL3.1919 mL15.9594 mL
10 mM0.1596 mL0.7980 mL1.5959 mL7.9797 mL
20 mM0.0798 mL0.3990 mL0.7980 mL3.9898 mL
50 mM0.0319 mL0.1596 mL0.3192 mL1.5959 mL
100 mM0.0160 mL0.0798 mL0.1596 mL0.7980 mL

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