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BW-A 78U

BW-A 78U
BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release.
Catalog No. T5101Cas No. 101155-02-6
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Purity:99.65%
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BW-A 78U

Purity: 99.65%
Catalog No. T5101Alias BW-A78UCas No. 101155-02-6

BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$33In Stock
5 mg$103In Stock
10 mg$155In Stock
25 mg$262In Stock
50 mg$377In Stock
100 mg$533In Stock
200 mg$732In Stock
1 mL x 10 mM (in DMSO)$37In Stock
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Product Introduction

Bioactivity
Description
BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release.
Targets&IC50
PDE4:3 μM
Cell Research
Mononuclear cells were incubated for 30 min with BW-A 78U (0.01-10 μM). The cells were then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants were collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants were determined by specific ELISA using a commercial kit. The sensitivity of the assay was 1 pg/mL. The absorbance at 450 nm was assessed with an ELISA reader.
AliasBW-A78U
Chemical Properties
Molecular Weight257.27
FormulaC13H12FN5
Cas No.101155-02-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (174.91 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8870 mL19.4348 mL38.8697 mL194.3483 mL
5 mM0.7774 mL3.8870 mL7.7739 mL38.8697 mL
10 mM0.3887 mL1.9435 mL3.8870 mL19.4348 mL
20 mM0.1943 mL0.9717 mL1.9435 mL9.7174 mL
50 mM0.0777 mL0.3887 mL0.7774 mL3.8870 mL
100 mM0.0389 mL0.1943 mL0.3887 mL1.9435 mL

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