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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
5 mg | $103 | In Stock | |
10 mg | $155 | In Stock | |
25 mg | $262 | In Stock | |
50 mg | $377 | In Stock | |
100 mg | $533 | In Stock | |
200 mg | $732 | In Stock | |
1 mL x 10 mM (in DMSO) | $37 | In Stock |
Description | BW-A 78U, a PDE4 inhibitor (IC50: 3 μM), does not inhibit lipopolysaccharide (LPS)-induced TNF-α release. |
Targets&IC50 | PDE4:3 μM |
Cell Research | Mononuclear cells were incubated for 30 min with BW-A 78U (0.01-10 μM). The cells were then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants were collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants were determined by specific ELISA using a commercial kit. The sensitivity of the assay was 1 pg/mL. The absorbance at 450 nm was assessed with an ELISA reader. |
Alias | BW-A78U |
Molecular Weight | 257.27 |
Formula | C13H12FN5 |
Cas No. | 101155-02-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (174.91 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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