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Bacopaside X
Catalog No. TN1424Cas No. 94443-88-6
Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
Bacopaside X
Catalog No. TN1424Cas No. 94443-88-6
Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $233 | 35 days | |
| 5 mg | $745 | 35 days | |
| 10 mg | $1,360 | 35 days | |
| 25 mg | $2,840 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor. |
| In vitro | The compounds were docked into 5-HT1A, 5-HT2A, D1, D2, M1 receptors and acetylcholinesterase (AChE) using AutoDock and their central nervous system (CNS) drug-like properties were determined using Discovery Studio molecular properties and ADMET descriptors. The compounds were screened in vitro using radioligand receptor binding and AChE inhibition assays. In silico studies showed that the parent bacosides were not able to dock into the chosen CNS targets and had poor molecular properties as a CNS drug. In contrast, the aglycones and their derivatives showed better binding affinity and good CNS drug-like properties, were well absorbed through the intestines and had good blood brain barrier (BBB) penetration. Among the compounds tested in vitro, ebelin lactone showed binding affinity towards M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) receptors. Bacoside A and Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor. |
| Molecular Weight | 899.07 |
| Formula | C46H74O17 |
| Cas No. | 94443-88-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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