Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 127.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 443.00 | |
25 mg | In stock | $ 732.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,390.00 | |
500 mg | In stock | $ 2,790.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 342.00 |
Description | Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). |
Targets&IC50 | mGlu5 receptor:1.1 nM (Kd) |
In vitro | In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM). Basimglurant shows similar potencies in radioligand binding and functional assay on human and rodent mGlu5 receptor orthologues[1]. |
In vivo | Basimglurant is selective and safe inhibitor of mGlu5 with good oral bioavailability and long half-life supportive of once-daily administration, good brain penetration, and high in vivo potency. Basimglurant has antidepressant properties which are corroborated by its functional magnetic imaging (fMRI) profile, as well as anxiolytic-like and antinociceptive features[1]. |
Synonyms | CTEP Derivative, RG7090 |
Molecular Weight | 325.77 |
Formula | C18H13ClFN3 |
CAS No. | 802906-73-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (102.31 mM)
You can also refer to dose conversion for different animals. More
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Basimglurant 802906-73-6 Neuroscience GluR Inhibitor RG-7090 Metabotropic glutamate receptors mGluR inhibit CTEP Derivative RG7090 RG 7090 inhibitor