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Bay K 8644

Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

Catalog No. T6777Cas No. 71145-03-4

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Purity:99.97%

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COA HNMR HPLC

Bay K 8644

Catalog No. T6777Cas No. 71145-03-4

Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$80	In Stock
10 mg	$128	In Stock
25 mg	$263	In Stock
50 mg	$416	In Stock
100 mg	$618	In Stock

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Product Introduction

Bioactivity

Description	Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.
Targets&IC50	Ca2+ channel, L-type:17.3nM(EC50)
In vitro	Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2]
In vivo	Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3]
Alias	(±)-BAY-K-8644, SQ 28,873

Chemical Properties

Molecular Weight	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Cas No.	71145-03-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 35.6 mg/mL (100 mM)

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8066 mL	14.0331 mL	28.0662 mL	140.3312 mL
5 mM	0.5613 mL	2.8066 mL	5.6132 mL	28.0662 mL
10 mM	0.2807 mL	1.4033 mL	2.8066 mL	14.0331 mL
20 mM	0.1403 mL	0.7017 mL	1.4033 mL	7.0166 mL
50 mM	0.0561 mL	0.2807 mL	0.5613 mL	2.8066 mL
100 mM	0.0281 mL	0.1403 mL	0.2807 mL	1.4033 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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