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Bergapten

Catalog No. T2143 CAS 484-20-8

Synonyms: 5-Methoxypsoralen

Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bergapten, CAS 484-20-8

Pack Size	Availability	Price/USD
500 mg	In stock	$ 68.00
1 g	In stock	$ 117.00
5 g	In stock	$ 473.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.95%

Purity: 99.83%

Purity: 99.77%

Purity: 99.48%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
In vitro	In C57BL/6J mice induced with acetaminophen (APAP), Bergapten exhibits antioxidant activity and mitigates hepatotoxicity.
In vivo	In both tamoxifen-sensitive and -resistant breast cancer cells, Bergapten eliminates ERα and reprograms membrane signaling targeted at ERα, thereby enhancing the potential for cell mitosis.
Cell Research	5-Methoxypsoralen (5-MOP) is dissolved in DMSO and stored, and then diluted with appropriate medium (final DMSO <0.1%) before use[1]. The human colon adenocarcinoma cell line (COLO 205, from a 70-year-old male Caucasian) sre placed into 75-cm2 tissue culture flasks and grown in RPMI1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. The human stomach adenocarcinoma cell line are placed into 75-cm2 tissue culture flasks and grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. SC-M1 and COLO 205 cells are treated with different concentrations of 5-MOP (0.05, 0.5, 5, 10, 25 and 50 mM) and incubated for 72 h for the dose-effect study of 5-MOP on NAT activity. To determine the time-course effect of 0.5 mM 5-MOP on NAT activity, the cells are incubated at 37AC and harvested at 12, 24, 48 and 72 h, respectively. 5-MOP is dissolved in DMSO and the final concentration of vehicle is <0.1%. Only DMSO (solvent) is added for the control regimen[1].
Source	Natural Products > Moraceae > Ficus

Synonyms	5-Methoxypsoralen
Molecular Weight	216.19
Formula	C12H8O4
CAS No.	484-20-8

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 5 mg/mL (23.12 mM), The compound is unstable in solution. Please use soon.

References and Literature

1. Panno ML, et al. Breast Cancer Res Treat, 2012, 136(2), 443-455. 2. Liu WX, et al. World J Gastroenterol, 2012, 18(18), 2197-2202.

Citations

1. Gao S, Zou X, Wang Z, et al. Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1. 3 and Carbonyl reductase 1. European Journal of Pharmacology. 2022: 175242.

Related compound libraries

This product is contained In the following compound libraries：

Tobacco Monomer Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Inhibitor Library Target-Focused Phenotypic Screening Library Natural Product Library Natural Product Library for HTS Metabolism Compound Library Autophagy Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Bergapten 484-20-8 Autophagy Metabolism P450 inhibit Inhibitor CYPs 5-Methoxypsoralen Cytochrome P450 inhibitor

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