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Beta-Tocopherol

Catalog No. TN1441   CAS 148-03-8

Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).

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Beta-Tocopherol Chemical Structure
Beta-Tocopherol, CAS 148-03-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 54.00
2 mg In stock $ 79.00
5 mg In stock $ 128.00
10 mg In stock $ 212.00
25 mg In stock $ 359.00
50 mg In stock $ 535.00
1 mL * 10 mM (in DMSO) In stock $ 156.00
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Purity: 99.81%
Purity: 99.8%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
In vitro Adhesion induced by PMA stimulation was prevented by 44.5% by physiological concentrations of alpha-tocopherol. Under the same experimental conditions, Beta-Tocopherol, an analogue of alpha-tocopherol, produced 11% inhibition of adhesion. Cell response gradually increased from 0 to 24 h of alpha-tocopherol treatment. Only a slight time dependency of Beta-Tocopherol inhibition was observed. Another human erythroleukemia cell line (K562) and the human monocyte tumor cell line U937 showed 5.0 and 11.2% inhibition, respectively. Similar to alpha-tocopherol, the protein kinase C inhibitor, Calphostin C, and the MAPK inhibitor, PD98059, prevented PMA-induced cell adhesion. An inhibition of ERK-1 phosphorylation was observed for alpha-tocopherol only in HEL, implying that MAP kinase pathway is involved in this cell line.
Source
Molecular Weight 416.68
Formula C28H48O2
CAS No. 148-03-8

Storage

store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (179.99 mM)

TargetMolReferences and Literature

1. Breyer I, Azzi A. Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: role of integrins. Free Radic Biol Med. 2001 Jun 15;30(12):1381-9.

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This product is contained In the following compound libraries:
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Keywords

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