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Bimatoprost

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Purity:100%

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COA HNMR HPLC

Bimatoprost

Catalog No. T2538Cas No. 155206-00-1

Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$81	In Stock
25 mg	$150	In Stock
50 mg	$271	In Stock
100 mg	$458	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Product Introduction

Bioactivity

Description	Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
In vitro	Bimatoprost is an effective prostaglandin FP receptor agonist, capable of directly inducing a robust and rapid return of calcium ions to baseline levels. It directly activates FP prostaglandin receptors in rats, mice, and humans.
In vivo	Bimatoprost displaces [3H] prostaglandin F (2alpha) binding to FP receptors with a Ki of 6.31 μM. It rapidly mobilizes intracellular calcium in 3T3 mouse fibroblasts expressing FP receptors (EC50: 2.2 μM) and human embryonic kidney cells with human FP receptors (EC50: 2.94 μM). Bimatoprost upregulates Cyr61 expression in feline irises and mildly stimulates aqueous humor outflow rate, increasing it by 13% during the day and 14% at night, while reducing tonographic outflow by 26%, thereby lowering intraocular pressure.
Alias	AGN 192024

Chemical Properties

Molecular Weight	415.57
Formula	C25H37NO4
Cas No.	155206-00-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 34 mg/mL (81.8 mM)

Ethanol: 77 mg/mL (185.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4063 mL	12.0317 mL	24.0633 mL	120.3167 mL
5 mM	0.4813 mL	2.4063 mL	4.8127 mL	24.0633 mL
10 mM	0.2406 mL	1.2032 mL	2.4063 mL	12.0317 mL
20 mM	0.1203 mL	0.6016 mL	1.2032 mL	6.0158 mL
50 mM	0.0481 mL	0.2406 mL	0.4813 mL	2.4063 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0241 mL	0.1203 mL	0.2406 mL	1.2032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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