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Borussertib

Catalog No. T8427   CAS 1800070-77-2

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)

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Borussertib Chemical Structure
Borussertib, CAS 1800070-77-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 135.00
5 mg In stock $ 289.00
10 mg In stock $ 455.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 379.00
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Purity: 98.18%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)
Targets&IC50 Aktwt:0.8 nM, Aktwt:2.2 nM (ki)
In vitro Borussertib exhibits excellent cellular activity in the nanomolar range with superior profile against clinical candidate Akt inhibitors as well as the cytostatic drug doxorubicin. With the EC50 values are 191±90 nM, 48±15 nM, 5±1 nM, 277±90 nM, 373±54 nM, 7770±641 nM in AN3CA (endometrium), T47D (breast), ZR-75-1 (breast), MCF-7 (breast), BT-474 (breast) and KU-19-19 (bladder) cell lines, respectively[1].
Molecular Weight 596.68
Formula C36H32N6O3
CAS No. 1800070-77-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (41.90 mM), sonification is recommended.

TargetMolReferences and Literature

1. Niklas Uhlenbrock, et al. Structural and chemical insights into the covalentallosteric inhibition of the protein kinase Akt. Chem Sci., 2019, 10, 3573.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Glycolysis Compound Library Inhibitor Library Antioxidant Compound Library Bioactive Compound Library Covalent Inhibitor Library Reprogramming Compound Library Autophagy Compound Library

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Keywords

Borussertib 1800070-77-2 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt Inhibitor PKB Protein kinase B inhibit inhibitor

 

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