Home Tools

Bucladesine sodium

Catalog No. T1418 CAS 16980-89-5

Synonyms: dbcAMP, Dibutyryl-cAMP sodium salt, Dibutyryl-cAMP, DC2797, Sodium dibutyryl cAMP, Bucladesine, Bucladesine sodium salt

Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bucladesine sodium, CAS 16980-89-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 31.00
50 mg	In stock	$ 42.00
100 mg	In stock	$ 79.00
200 mg	In stock	$ 117.00
500 mg	In stock	$ 193.00
2 g	In stock	$ 419.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

Bulk Inquiry

Select Batch

Purity: 99.58%

Purity: 98.35%

Purity: 98.34%

Purity: 98.11%

Purity: 97.81%

Purity: 97.27%

Purity: 96.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.
In vitro	METHODS: Human eosinophil EoL-1 cells were treated with Bucladesine sodium (10-100 µM) for 8 days and activity was measured using PKA assay. RESULTS: Proliferation of EoL-1 cells treated with Bucladesine sodium increased in a time-dependent manner. [1] METHODS: PC12 cells were treated with Bucladesine sodium (1 mM) for 72 h. TNF-α levels were measured by ELISA assay. RESULTS: Bucladesine sodium increased the activity of PKA. [2]
In vivo	METHODS: To study the anti-inflammatory activity in vivo, Bucladesine sodium (0.24-0.7 µg/kg) was administered intraperitoneally to a mouse model of copper pine demyelination once daily for seven days. RESULTS: Bucladesine had a protective effect on myelin formation. Enhanced intracellular cAMP prevented demyelination and exerted anti-inflammatory and anti-apoptotic properties in a mouse model of copper pine demyelination. [3] METHODS: To investigate the effects on liver injury, Bucladesine sodium (0.5-500 mg/kg) was intraperitoneally injected into C57BL/6J jcl mice, and liver injury was induced by the intravenous injection of rTNF-α (1.0 µg/kg) and intraperitoneal injection of D-gal (500 mg/kg) after 1 h. The RESULTS showed that Bucladesine protected against hepatic injury in C57BL/6J jcl mice. RESULTS: Bucladesine protected mice from TNF-α/D-gal-induced liver injury.Bucladesine significantly enhanced the expression of Hsp70 in hepatocytes of D-gal/TNFα-injected mice, which was closely related to the inhibition of liver injury. [4]
Animal Research	Animal: Mice. Formulation: water/DMSO (9:1). Dosages: 600 nM. Administration: i.p.

Synonyms	dbcAMP, Dibutyryl-cAMP sodium salt, Dibutyryl-cAMP, DC2797, Sodium dibutyryl cAMP, Bucladesine, Bucladesine sodium salt
Molecular Weight	491.37
Formula	C18H23N5NaO8P
CAS No.	16980-89-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 49.1 mg/mL (100 mM)

DMSO: 49.1 mg/mL (100 mM)

References and Literature

1. Jung Y. Comparative Analysis of Dibutyric cAMP and Butyric Acid on the Differentiation of Human Eosinophilic Leukemia EoL-1 Cells. Immune Netw. 2015 Dec;15(6):313-8. 2. Shimojo M, et al. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem. 1998 Sep;71(3):1118-26. 3. Vakilzadeh G, et al. Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination. Mol Neurobiol. 2015 Aug;52(1):130-41. 4. Takano M, et al. Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression. Cell Stress Chaperones. 1998 Jun;3(2):109-17. 5. Xu C, Zhao W, Huang X, et al. TORC2/3-mediated DUSP1 upregulation is essential for human decidualization[J]. Reproduction. 2021, 1(aop).

Citations

1. Cui L, Xu F, Xu C, et al.Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis.Journal of Biomedical Science.2022, 29(1): 1-14. 2. Zhang L, Wan M, Tohti R, et al.Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.International Journal of Molecular Sciences.2022, 23(22): 14182. 3. Zhao W, Xu C, Peng L, et al.cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization.Molecular and Cellular Endocrinology.2023: 111946. 4. Chen L, Zhao W, Li M, et al.SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor.Reproduction.2023, 1(aop). 5. Xu C, Zhao W, Huang X, et al. TORC2/3-mediated DUSP1 upregulation is essential for human decidualization. Reproduction. 2021, 1(aop). 6. Jiang N X, Zhao W J, Shen H R, et al.Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling: new insight into polycystic ovary syndrome (PCOS)-related infertility.Journal of Ovarian Research.2024, 17(1): 1-13.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Anti-Viral Compound Library Autophagy Compound Library Metabolism Compound Library

Related Products

Related compounds with same targets

AP-C2 LX7101 AT13148 Ellagic acid Protein kinase G inhibitor-1 KT5823 KT5720 OSIP-486823

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bucladesine sodium 16980-89-5 Metabolism Tyrosine Kinase/Adaptors PKA PDE Phosphodiesterase (PDE) CA1 DC-2797 memory anti-inflammatory Dibutyryl cAMP spatial dbcAMP Dibutyryl-cAMP sodium Dibutyryl-cAMP sodium salt ChAT inhibit Protein kinase A cAMP lipophilic DC 2797 Dibutyryl-cAMP Inhibitor DC2797 Sodium dibutyryl cAMP Bucladesine intracellular Bucladesine sodium salt VAChT inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.