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Buparvaquone

Catalog No. T4269 CAS 88426-33-9

Synonyms: Butalex, BW 720C

Buparvaquone (BW 720C) is a hydroxynaphthoquinone antiprotozoal drug related to atovaquone and parvaquone.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Buparvaquone, CAS 88426-33-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 42.00
50 mg	In stock	$ 58.00
100 mg	In stock	$ 74.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Buparvaquone (BW 720C) is a hydroxynaphthoquinone antiprotozoal drug related to atovaquone and parvaquone.
In vitro	Buparvaquone is significantly selective against L. (L.) infantum chagasi intracellular amastigotes, with an IC50 value of 1.5 μM. In 4-day proliferation assays, buparvaquone efficiently inhibits N.?caninum tachyzoite replication(IC50=4.9?nM; IC100=100?nM). Other cutaneous species are also susceptible to buparvaquone, with IC50 values in the range 1-4 μM.
In vivo	Both a hydrous gel and a water-in-oil emulsion containing buparvaquone markedly decrease the cutaneous parasite load and lesion size compared to the untreated control. Administering buparvaquone (100 mg/kg) to N. caninum-infected mice, either through intraperitoneal injection or orally via gavage, effectively prevents neosporosis symptoms in a significant proportion of the subjects. Specifically, symptoms were prevented in four out of six mice in the group treated intraperitoneally and in six out of seven mice receiving oral treatment.
Cell Research	To study whether pretreatment of host cells prior to invasion had any effect on parasite proliferation, confluent HFF grown in 6-well plates are treated with 1?μM buparvaquone in medium for 1?h or 5?h, and controls are exposed to the corresponding amounts of DMSO. Subsequently, the drug-containing medium is removed and monolayers are ished 4 times with Hank's Balanced Salt Solution, and are infected with Nc-Liv tachyzoites in 5?mL medium without any drug or solvent. After 2 days, cells are collected with a cell scraper, centrifuged, ished once more in PBS, and the pellet is stored at ?20?°C prior to quantification of N.?caninum proliferation by N.?caninum-specific real time PCR as outlined below.
Animal Research	Mice: On day 0, all mice are infected by intraperitoneal (i.p.) injection of freshly purified N.?caninum tachyzoites. After 48?h, mice receive BPQ (100?mg/kg) as suspension in corn oil either by i.p. injection of a volume of 100?μl or by oral application of 100?μl by gavage. The control groups obtained the corresponding amount of the solvent only, either i.p. or orally. The treatments are performed 5 times on a daily basis. If not indicated otherwise, mice are inspected twice daily for clinical signs (ruffled coat, apathy, hind limb paralysis) until day 21 post infection (p.i.), at which time they are euthanized.

Synonyms	Butalex, BW 720C
Molecular Weight	326.43
Formula	C21H26O3
CAS No.	88426-33-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.26 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Müller J, et al. Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. Int J Parasitol Drugs Drug Resist. 2015 Feb 13;5(1):16-25. 2. Reimão JQ, et al. Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi. Exp Parasitol. 2012 Mar;130(3):195-9. 3. Garnier T, et al. In vivo studies on the antileishmanial activity of buparvaquone and its prodrugs. J Antimicrob Chemother. 2007 Oct;60(4):802-10.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Anti-Infection Compound Library Bioactive Compounds Library Max Antibiotics Library FDA-Approved & Pharmacopeia Drug Library Immunology/Inflammation Compound Library Human Metabolite Library Bioactive Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Buparvaquone 88426-33-9 Microbiology/Virology Antibiotic Parasite Inhibitor Butalex BW 720C inhibit inhibitor

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