Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Butylparaben (Butyl 4-hydroxybenzoate) is a standardized chemical allergen, increasing histamine release, and cell-mediated immunity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 g | In stock | $ 47.00 | |
10 g | In stock | $ 68.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 29.00 |
Description | Butylparaben (Butyl 4-hydroxybenzoate) is a standardized chemical allergen, increasing histamine release, and cell-mediated immunity. |
In vitro | After butylparaben treatment, vimentin filaments in Sertolicells are disrupted. Sertoli cell cytoskeleton responds to butylparaben by exhibiting a marked collapse in vimentin filaments distribution[1]. |
In vivo | Butylparaben induces collapse of Sertoli cell vimentin filaments in vivo[1]. Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system[2]. |
Cell Research | Mixed cultures of Sertoli and spermatogenic cells are prepared from three-week-old SD rats. Single cells are obtained by gravity sedimentation and use of 50% trypsin-EDTA. Cells are finally suspended at a concentration of 1 × 108cell/ml and maintained for 24 h in Dulbecco’s modified Eagle medium supplemented with 100 U/ml penicillin, 100 μg/ml streptomycin, and 10% fetal bovineserum. Thereafter, cells are maintained in serum-freemedium, which is changed every 24 h. At 72 h, spermatogenic cells are removed by treatment with hypotonic Tris buffer (20 mMTris–HCl, pH 7.4) for 5 min. The Sertoli cell-enriched cultures obtained are then maintained in serum-free medium for 24 h before being reseeded onto chamber slides. The samples are cultured for a further 5 days. Subsequently, they are exposed to 0, 1, 100 and 1000 nmol/ml butylparaben for 6 and 24 h. Some slides are stained with 0.5% toluidine blue for light microscopic observations, whereas the rest are used for vimentin immuno-histochemical analysis. (Only for Reference) |
Synonyms | Butyl 4-hydroxybenzoate, Butyl parahydroxybenzoate |
Molecular Weight | 194.23 |
Formula | C11H14O3 |
CAS No. | 94-26-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 35 mg/mL (180.2 mM)
DMSO: 36 mg/mL (185.3 mM)
Ethanol: 36 mg/mL (185.3 mM)
You can also refer to dose conversion for different animals. More
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Butylparaben 94-26-8 Metabolism Microbiology/Virology Endogenous Metabolite Antibacterial Antibiotic Butyl 4-hydroxybenzoate inhibit Bacterial Butyl parahydroxybenzoate Butyl paraben Inhibitor inhibitor