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CB1-IN-1

Catalog No. T5996 CAS 1429239-98-4

Synonyms: DBPR211

CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.

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CB1-IN-1, CAS 1429239-98-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
2 mg	In stock	$ 197.00
5 mg	In stock	$ 333.00
10 mg	In stock	$ 477.00
25 mg	In stock	$ 782.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,470.00
500 mg	In stock	$ 2,950.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Purity: 99.55%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CB1-IN-1 (DBPR211) is a peripherally restricted CB1R antagonist, for CB1R and CB2R with Ki of 0.3 nM and 21 nM,respectively.
Targets&IC50	CB2 receptor:21 nM, CB1 receptor:0.3 nM

Synonyms	DBPR211
Molecular Weight	751.67
Formula	C33H31Cl2F3N6O3S2
CAS No.	1429239-98-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (14.63 mM)

References and Literature

1. Chang C P , Wu C H , Song J S , et al. Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.[J]. Journal of Medicinal Chemistry, 2013, 56(24):9920. 2. Chang C P , Huang H L , Huang J K , et al. Fluorine-18 Isotope Labeling for Positron Emission Tomography Imaging. Direct Evidence for DBPR211 as a Peripherally Restricted CB1 Inverse Agonist[J]. Bioorganic & Medicinal Chemistry, 2018.

Citations

1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Anti-Fibrosis Compound Library Bioactive Compound Library Neuronal Signaling Compound Library NO PAINS Compound Library ReFRAME Related Library

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Hemopressin (human, mouse) acetate ML-193 CB2R agonist 3 Tetrahydromagnolol Olorinab Hemopressin(human, mouse) TFA Hemopressin (rat) acetate(568588-77-2 free base) N-Arachidonyldopamine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CB1-IN-1 1429239-98-4 GPCR/G Protein Cannabinoid Receptor DBPR 211 Inhibitor DBPR211 inhibit BPRCB 1184 CB1IN1 BPRCB-1184 BPRCB1184 CB-1-IN-1 CB1 IN 1 DBPR-211 inhibitor

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