Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 848.00 | |
5 mg | In stock | $ 1,680.00 | |
10 mg | In stock | $ 2,270.00 | |
25 mg | In stock | $ 3,370.00 | |
50 mg | In stock | $ 4,530.00 | |
100 mg | In stock | $ 6,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 1,920.00 |
Description | CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. |
In vitro | CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain. |
In vivo | In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and has a neuroprotective effect following hypoxic/ischaemic brain injury in neonatal rats[1]. |
Synonyms | CNS 5161A |
Molecular Weight | 388.38 |
Formula | C16H19Cl2N3S2 |
CAS No. | 160756-38-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (141.61 mM)
You can also refer to dose conversion for different animals. More
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CNS-5161 hydrochloride 160756-38-7 Neuroscience NMDAR CNS-5161 Hydrochloride CNS 5161 Hydrochloride CNS5161 Hydrochloride CNS 5161A inhibitor inhibit