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CNS-5161 hydrochloride

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Catalog No. T10852Cas No. 160756-38-7
Alias CNS 5161A

CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

CNS-5161 hydrochloride

CNS-5161 hydrochloride

🥰Excellent
Purity: 99.53%
Catalog No. T10852Alias CNS 5161ACas No. 160756-38-7
CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
Pack SizePriceAvailabilityQuantity
1 mg483 €In Stock
5 mg950 €In Stock
10 mg1.292 €In Stock
25 mg1.919 €In Stock
50 mg2.574 €In Stock
1 mL x 10 mM (in DMSO)1.092 €In Stock
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Purity:99.53%
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Product Introduction

Bioactivity
Description
CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
In vitro
CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain.
In vivo
In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (i.p.) protects against the necrotic effects of exogenous N-methyl-D-aspartate (ED80: 4 mg/kg). CNS-5161 also demonstrates a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p. and exhibits neuroprotective effects following hypoxic/ischaemic brain injury in neonatal rats[1].
AliasCNS 5161A
Chemical Properties
Molecular Weight388.38
FormulaC16H19Cl2N3S2
Cas No.160756-38-7
SmilesCl.ClC1=CC=C(SC)C=C1NC(=N)N(C=2C=CC=C(SC)C2)C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (141.61 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5748 mL12.8740 mL25.7480 mL128.7399 mL
5 mM0.5150 mL2.5748 mL5.1496 mL25.7480 mL
10 mM0.2575 mL1.2874 mL2.5748 mL12.8740 mL
20 mM0.1287 mL0.6437 mL1.2874 mL6.4370 mL
50 mM0.0515 mL0.2575 mL0.5150 mL2.5748 mL
100 mM0.0257 mL0.1287 mL0.2575 mL1.2874 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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