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Cynarin

Catalog No. T6S1529 CAS 30964-13-7

Synonyms: Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-, Cynarine, 1,5-Dicaffeoylquinic acid

Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax.

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Cynarin, CAS 30964-13-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 52.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 322.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 99.74%

Purity: 99.48%

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Chemical Properties

Storage & Solubility Information

Description	Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax.
In vitro	1,5-Dicaffeoylquinic acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein.1, 5-diCQA has antioxidant signaling properties that upregulate GSH synthesis by stimulating the Nrf2 pathway in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion[1].1,5-Dicaffeoylquinic acid decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture[2].
Kinase Assay	The processing of an in vitro model of ischemia/reperfusion was described previously. The cultures were washed three times with deoxygenated glucose-free DMEM and placed into an anaerobic chamber with an atmosphere of 10% H2, 85% N2, and 5% CO2 for 4 h. Then the glucose-free DMEM was replaced with complete medium, and the culture plates were maintained at 37 C in a humidified 5% CO2-containing atmosphere for an additional 20 h. As a pretreatment, different concentrations of 1, 5-diCQA were added to the media before OGD for 2 h[1].
Source	Natural Products > Caprifoliaceae > Lonicera

Synonyms	Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-, Cynarine, 1,5-Dicaffeoylquinic acid
Molecular Weight	516.45
Formula	C25H24O12
CAS No.	30964-13-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL (44.53 mM)

References and Literature

1. Cao X, et al. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes.Brain Res. 2010 Aug 6;1347:142-8 2. Xia N , Pautz A , Wollscheid U , et al. Artichoke, Cynarin and Cyanidin Downregulate the Expression of Inducible Nitric Oxide Synthase in Human Coronary Smooth Muscle Cells[J]. Molecules, 2014, 19(3):3654-3668.

Citations

1. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Anti-Obesity Compound Library Human Endogenous Metabolite Compound Library Plus Polyphenolic Natural Product Library Anti-Breast Cancer Compound Library Covalent Inhibitor Library Anti-Viral Compound Library NF-κB Signaling Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Keywords

Cynarin 30964-13-7 Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb oxidation-reduction Influenza Virus Reactive Oxygen Species Antiviral Antioxidant Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)- Cynarine 1,5-Dicaffeoylquinic acid inhibit Inhibitor inhibitor

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