Shopping Cart
- Remove All
- Your shopping cart is currently empty
CZC24832 is a selective inhibitor of PI 3-kinase γ.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $43 | In Stock | |
2 mg | $61 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $148 | In Stock | |
25 mg | $252 | In Stock | |
50 mg | $375 | In Stock | |
100 mg | $553 | In Stock | |
1 mL x 10 mM (in DMSO) | $112 | In Stock |
Description | CZC24832 is a selective inhibitor of PI 3-kinase γ. |
Targets&IC50 | PI3Kγ:27 nM, PI3Kβ:1.1 μM |
In vitro | In a therapeutic model of collagen-induced arthritis (CIA), mice administered 10 mg/kg of CZC24832 orally twice daily exhibited significant reductions in both bone and cartilage destruction and overall clinical parameters. Additionally, in an IL-8-dependent air-pouch model, CZC24832 demonstrated a dose-dependent decrease in granulocyte recruitment, consistent with the level of inhibition observed in mice lacking PI3Kγ. |
In vivo | In the BT system, treatment with CZC24832 significantly inhibits IL-17A (IC50 = 1.5 μM) as well as B-cell activation markers, such as IL-6 and IgG. Moreover, in T-cell systems, such as in human umbilical vein endothelial cells, the production of IL17A is strongly suppressed, indicating that PI3Kγ kinase activity plays a broad role in the functionality of TH17 cells. Accordingly, CZC24832 inhibits the differentiation of TH17 cells. A high-throughput screening of 154 lipid and protein kinases, alongside 922 other proteins, identified only PI3Kβ and PIP4K2C as off-target proteins within a 100-fold selectivity window. |
Kinase Assay | AZD4547 kinase activity: The ability of AZD4547 to inhibit the human recombinant kinase activities of FGFR1-3 is tested using ATP concentrations at, or just below, the respective Km. |
Molecular Weight | 364.4 |
Formula | C15H17FN6O2S |
Cas No. | 1159824-67-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 36.4 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.