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CZC24832

Catalog No. T1949Cas No. 1159824-67-5

CZC24832 is a selective inhibitor of PI 3-kinase γ.

CZC24832

CZC24832

Purity: 99.12%
Catalog No. T1949Cas No. 1159824-67-5
CZC24832 is a selective inhibitor of PI 3-kinase γ.
Pack SizePriceAvailabilityQuantity
1 mg$43In Stock
2 mg$61In Stock
5 mg$98In Stock
10 mg$148In Stock
25 mg$252In Stock
50 mg$375In Stock
100 mg$553In Stock
1 mL x 10 mM (in DMSO)$112In Stock
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Purity:99.12%
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Product Introduction

Bioactivity
Description
CZC24832 is a selective inhibitor of PI 3-kinase γ.
Targets&IC50
PI3Kγ:27 nM, PI3Kβ:1.1 μM
In vitro
In a therapeutic model of collagen-induced arthritis (CIA), mice administered 10 mg/kg of CZC24832 orally twice daily exhibited significant reductions in both bone and cartilage destruction and overall clinical parameters. Additionally, in an IL-8-dependent air-pouch model, CZC24832 demonstrated a dose-dependent decrease in granulocyte recruitment, consistent with the level of inhibition observed in mice lacking PI3Kγ.
In vivo
In the BT system, treatment with CZC24832 significantly inhibits IL-17A (IC50 = 1.5 μM) as well as B-cell activation markers, such as IL-6 and IgG. Moreover, in T-cell systems, such as in human umbilical vein endothelial cells, the production of IL17A is strongly suppressed, indicating that PI3Kγ kinase activity plays a broad role in the functionality of TH17 cells. Accordingly, CZC24832 inhibits the differentiation of TH17 cells. A high-throughput screening of 154 lipid and protein kinases, alongside 922 other proteins, identified only PI3Kβ and PIP4K2C as off-target proteins within a 100-fold selectivity window.
Kinase Assay
AZD4547 kinase activity: The ability of AZD4547 to inhibit the human recombinant kinase activities of FGFR1-3 is tested using ATP concentrations at, or just below, the respective Km.
Chemical Properties
Molecular Weight364.4
FormulaC15H17FN6O2S
Cas No.1159824-67-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 36.4 mg/mL (100 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7442 mL13.7212 mL27.4424 mL137.2119 mL
5 mM0.5488 mL2.7442 mL5.4885 mL27.4424 mL
10 mM0.2744 mL1.3721 mL2.7442 mL13.7212 mL
20 mM0.1372 mL0.6861 mL1.3721 mL6.8606 mL
50 mM0.0549 mL0.2744 mL0.5488 mL2.7442 mL
100 mM0.0274 mL0.1372 mL0.2744 mL1.3721 mL

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