store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the active ingredients in the naphthylpyrone reference extract (NRE).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 276.00 | |
5 mg | In stock | $ 639.00 | |
10 mg | In stock | $ 956.00 | |
25 mg | In stock | $ 1,420.00 | |
50 mg | In stock | $ 1,920.00 | |
100 mg | In stock | $ 2,590.00 |
Description | Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the active ingredients in the naphthylpyrone reference extract (NRE). |
Targets&IC50 | MAO-A:40.57 µM |
In vitro | Rubrofusarin showed potent inhibition against the PTP1B enzyme (IC50; 16.95 ± 0.49 μM), and its glycosides reduced activity (IC50; 87.36 ± 1.08 μM for 1 and >100 μM for 2-4) than did the reference drug, ursolic acid (IC50; 2.29 ± 0.04 μM). Similarly, in hMAO-A inhibition, rubrofusarin displayed the most potent activity with an IC50 value of 5.90 ± 0.99 μM, which was twice better than the reference drug, deprenyl HCl (IC50; 10.23 ± 0.82 μM). An enzyme kinetic and molecular docking study revealed rubrofusarin to be a mixed-competitive inhibitor of both these enzymes. In a western blot analysis, rubrofusarin increased glucose uptake significantly and decreased the PTP1B expression in a dose-dependent manner in insulin-resistant HepG2 cells, increased the expression of phosphorylated protein kinase B (p-Akt) and phosphorylated insulin receptor substrate-1 (p-IRS1) (Tyr 895), and decreased the expression of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK), key enzymes of gluconeogenesis. |
Molecular Weight | 920.82 |
Formula | C39H52O25 |
CAS No. | 218155-40-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50mg/mL(54.30 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Cassiaside B2 218155-40-9 GPCR/G Protein Metabolism Neuroscience Phosphatase MAO 5-HT Receptor Cassiaside B-2 inhibitor inhibit