Home Tools

Celgosivir

Catalog No. T10755L CAS 121104-96-9

Synonyms: MX3253, MBI 3253, 6 O-butanoyl castanospermine, MDL 28574

Celgosivir (6 O-butanoyl castanospermine) is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM ).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Celgosivir, CAS 121104-96-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 129.00
2 mg	In stock	$ 198.00
5 mg	In stock	$ 293.00
10 mg	In stock	$ 418.00
25 mg	In stock	$ 695.00
50 mg	In stock	$ 988.00
100 mg	In stock	$ 1,330.00
500 mg	In stock	$ 2,670.00

Bulk Inquiry

Select Batch

Purity: 98.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Celgosivir (6 O-butanoyl castanospermine) is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM ).
Targets&IC50	α-glucosidase I:1.27 μM
In vitro	Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0±2.3 μM) [1]. Celgosivir inhibits DENV2 replication (EC50: 0.2 μM). The EC50 values against DENV1, 3 and 4 are less than 0.7 μM[3]. Celgosivir is more effective (IC50=20 μM) than the parent molecule (IC50=254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Bovine viral diarrhoea virus (BVDV) is a closely related virus of hepatitis C virus (HCV). In plaque assay and cytopathic effect assay, Celgosivir inhibits BVDV, with IC50 values of 16 and 47 μM , respectively[2].
In vivo	Celgosivir demonstrates robust protection in AG129 mice against lethal infection from a mouse-adapted dengue virus, effectively administered at a dosage of 50 mg/kg twice daily (BID) for a duration of 5 days. This protective efficacy is maintained even when treatment onset is delayed by 48 hours. The outcomes suggest that celgosivir's protective capability is contingent upon both the dosage and the administration schedule, with a twice daily regimen of 50, 25, or 10 mg/kg proving superior to a single daily dose of 100 mg/kg in terms of survival. Specifically, during primary infection with the mouse-adapted DENV strain S221, there is a notable increase in viremia by day 3. However, an impressive 80% of mice survive until day 10, with the virus being completely eliminated by day 8[3].

Synonyms	MX3253, MBI 3253, 6 O-butanoyl castanospermine, MDL 28574
Molecular Weight	259.3
Formula	C12H21NO5
CAS No.	121104-96-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1.8mg/mL (6.9mM)

References and Literature

1. Taylor DL, et al. Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoylcastanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells. Antimicrob Agents Chemother. 1994 Aug;38(8):1780-7. 2. Rathore AP, et al. Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes andprotects against lethal challenge mouse model. Antiviral Res. 2011 Dec;92(3):453-60. 3. Whitby K, et al. Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C. Antivir Chem Chemother. 2004 May;15(3):141-51. 4. Watanabe S, et al. Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial. Antiviral Res. 2012 Oct;96(1):32-5.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compounds Library Max Bioactive Compound Library Clinical Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

α-Glucosidase-IN-25 Pinoresinol diglucoside α-Glucosidase-IN-22 α-Glucosidase-IN-33 Castanospermine Ceftezole sodium α-Amylase/α-Glucosidase-IN-5 Viscidulin III

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Celgosivir 121104-96-9 Metabolism Glucosidase MBI3253 MX3253 MX 3253 MDL28574 MBI 3253 6 O-butanoyl castanospermine MDL-28574 MDL 28574 MX-3253 MBI-3253 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.