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Ciliobrevin D

Catalog No. T14965 CAS 1370554-01-0

Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.

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Ciliobrevin D, CAS 1370554-01-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 58.00
2 mg	In stock	$ 84.00
5 mg	In stock	$ 143.00
10 mg	In stock	$ 226.00
25 mg	In stock	$ 446.00
50 mg	In stock	$ 657.00
100 mg	In stock	$ 918.00
1 mL * 10 mM (in DMSO)	In stock	$ 159.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity in vitro.
In vitro	Ciliobrevin D reversibly inhibits melanosome aggregation, however, the non-cilia-disrupting derivative had no discernible effect at comparable doses. Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels and it similarly abrogates the movement of peroxisomes in Drosophila S2 cells[1].
In vivo	In the testis in vivo, Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D perturbs spermatogenesis. The use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity[3].

Molecular Weight	392.62
Formula	C17H8Cl3N3O2
CAS No.	1370554-01-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (12.73 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Firestone AJ, et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 2012 Mar 18;484(7392):125-9. 2. Miao Y, et al. Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement. Cell Cycle. 2017;16(21):2139-2145. 3. Wen Q, et al. Dynein 1 supports spermatid transport and spermiation during spermatogenesis in the rat testis. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.

Citations

1. Zhang L, Wan M, Tohti R, et al.Requirement of Zebrafish Adcy3a and Adcy5 in Melanosome Dispersion and Melanocyte Stripe Formation.International Journal of Molecular Sciences.2022, 23(22): 14182.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library Microtubule-Targeted Compound Library Ion Channel Inhibitor Library Bioactive Compound Library Anti-Prostate Cancer Compound Library Wnt/Hedgehog/Notch Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library

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Keywords

Ciliobrevin D 1370554-01-0 GPCR/G Protein Membrane transporter/Ion channel Stem Cells Hedgehog/Smoothened ATPase inhibit melanosome spindles cytoplasmic γ-tubulin Inhibitor dynein ATPases Hedgehog peroxisomes aggregation inhibitor

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