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Cinacalcet hydrochloride

Catalog No. T2406 CAS 364782-34-3

Synonyms: Cinacalcet HCl, Cinacalcet, AMG-073 hydrochloride, AMG-073 HCl

Cinacalcet hydrochloride is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.

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Cinacalcet hydrochloride, CAS 364782-34-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cinacalcet hydrochloride is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.
Targets&IC50	CaSR:2.8 μM(EC50)

Synonyms	Cinacalcet HCl, Cinacalcet, AMG-073 hydrochloride, AMG-073 HCl
Molecular Weight	393.87
Formula	C22H23ClF3N
CAS No.	364782-34-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 39.4 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ureña P, et al. Kidney Int Suppl, 2003, (85), S91-96. 2. Dong BJ. Clin Ther, 2005, 27(11), 1725-1751.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cinacalcet hydrochloride 364782-34-3 GPCR/G Protein CaSR AMG-073 Cinacalcet HCl Cinacalcet Endogenous Metabolite Calcium-sensing receptor Inhibitor AMG 073 AMG-073 hydrochloride inhibit AMG-073 HCl AMG073 inhibitor

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