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Coumestrol

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Purity:99.23%

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COA HPLC HNMR

Coumestrol

Catalog No. TQ0295Cas No. 479-13-0

Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.

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Pack Size	Price	Availability
1 mg	$40	In Stock
5 mg	$77	In Stock
10 mg	$123	In Stock
25 mg	$263	In Stock
50 mg	$428	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

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Product Introduction

Bioactivity

Description

Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 μM). It exhibits activities against neurological disorders, cancers and autoimmune diseases.

In vitro

Coumestrol inhibits proliferation and induces apoptosis in MCF-7 cells, which is prevented by copper chelator neocuproine and ROS scavengers. Coumestrol treatment induces ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation [1]. Coumestrol inhibits viability and invasion and induces apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of the proliferation of ovarian carcinoma, are attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphorylation of AKT, p70S6K, ERK1/2, JNK1/2, and p90RSK is inactivated by coumestrol treatment in a dose- and time-dependent manner [2].

Chemical Properties

Molecular Weight	268.22
Formula	C15H8O5
Cas No.	479-13-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25mg/mL (93.21 mM)

Methanol: 20 mg/mL (74.57 mM)

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	3.7283 mL	18.6414 mL	37.2828 mL	186.4141 mL
5 mM	0.7457 mL	3.7283 mL	7.4566 mL	37.2828 mL
10 mM	0.3728 mL	1.8641 mL	3.7283 mL	18.6414 mL
20 mM	0.1864 mL	0.9321 mL	1.8641 mL	9.3207 mL
50 mM	0.0746 mL	0.3728 mL	0.7457 mL	3.7283 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8641 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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