Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 488.00 | |
100 mg | In stock | $ 712.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 137.00 |
Description | Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. |
Targets&IC50 | αVβ3 integrin:20 nM |
In vitro | Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2] |
In vivo | In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2] |
Synonyms | Cyclo(RGDyK) |
Molecular Weight | 847.72 |
Formula | C31H43F6N9O12 |
CAS No. | 250612-42-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 130 mg/mL(153.35 mM)
You can also refer to dose conversion for different animals. More
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Cyclo(RGDyK) trifluoroacetate 250612-42-1 Cytoskeletal Signaling Integrin Cyclo(RGDyK) Trifluoroacetate inhibit Cyclo(RGDyK) Inhibitor inhibitor