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Cyclo(RGDyK) trifluoroacetate

Cyclo(RGDyK) trifluoroacetate
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Catalog No. T6813Cas No. 250612-42-1
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Cyclo(RGDyK) trifluoroacetate

Catalog No. T6813Alias Cyclo(RGDyK)Cas No. 250612-42-1

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$89In Stock
10 mg$147In Stock
25 mg$297In Stock
50 mg$488In Stock
100 mg$712In Stock
1 mL x 10 mM (in DMSO)$137In Stock
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Product Introduction

Bioactivity
Description
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Targets&IC50
αvβ3 integrin:20 nM
In vitro
Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]
In vivo
In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]
AliasCyclo(RGDyK)
Chemical Properties
Molecular Weight847.72
FormulaC31H43F6N9O12
Cas No.250612-42-1
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 130 mg/mL (153.35 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1796 mL5.8982 mL11.7963 mL58.9817 mL
5 mM0.2359 mL1.1796 mL2.3593 mL11.7963 mL
10 mM0.1180 mL0.5898 mL1.1796 mL5.8982 mL
20 mM0.0590 mL0.2949 mL0.5898 mL2.9491 mL
50 mM0.0236 mL0.1180 mL0.2359 mL1.1796 mL
100 mM0.0118 mL0.0590 mL0.1180 mL0.5898 mL

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