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DCH36_06

Catalog No. T9373 CAS 593273-05-3

Synonyms: (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p300/CBP inhibitor

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DCH36_06, CAS 593273-05-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 74.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 322.00
25 mg	In stock	$ 572.00
50 mg	In stock	$ 822.00
100 mg	In stock	$ 1,130.00
500 mg	In stock	$ 2,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 212.00

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Purity: 98.32%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p300/CBP inhibitor
Targets&IC50	CBP:3.2 μM, p300:0.6 μM
In vitro	DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. The suppression of p300/CBP activity retarded cell proliferation in several leukemic cell lines.In addition, DCH36_06 arrested cell cycle at G1 phase and induced apoptosis via activation of capase3, caspase9 and PARP that elucidated the molecular mechanism of its anti-proliferation activity. In transcriptome analysis, DCH36_06 altered downstream gene expression and apoptotic pathways-related genes verified by real-time PCR[1].
In vivo	DCH36_06 blocked the leukemic xenograft growth in mice supporting its potential for?in vivo?use that underlies the therapeutic potential for p300/CBP inhibitors in clinical translation[1].

Synonyms	(5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Molecular Weight	372.83
Formula	C18H13ClN2O3S
CAS No.	593273-05-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (321.86 mM), Sonication is recommended.

References and Literature

1. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.[J]. Bioorganic & medicinal chemistry, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Epigenetics Compound Library Apoptosis Compound Library Histone Modification Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Hypertension Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

DCH36_06 593273-05-3 Apoptosis Chromatin/Epigenetic Epigenetic Reader Domain Histone Acetyltransferase HATs hypoacetylation DCH-36_06 inhibit antiproliferative p300 HAT Inhibitor (5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione anti-tumor CBP inhibitor

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