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DG172 dihydrochloride

Catalog No. T7821 CAS 1361504-77-9

Synonyms: DG172 (dihydrochloride), DG-172 dihydrochloride

DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).

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DG172 dihydrochloride Chemical Structure

DG172 dihydrochloride, CAS 1361504-77-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 322.00
100 mg	In stock	$ 522.00

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Purity: 100%

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Description	DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
Targets&IC50	PPARβ/δ:27 nM
In vitro	DG172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC(50) = 27 nM) and potent inverse agonistic properties.?DG172 selectively inhibited the agonist-induced activity of PPARβ/δ, enhanced transcriptional corepressor recruitment, and down-regulated transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC(50) = 9.5 nM).?Importantly, DG172 was bioavailable after oral application to mice with peak plasma levels in the concentration range of its maximal inhibitory potency, suggesting that 37 will be an invaluable tool to elucidate the functions and therapeutic potential of PPARβ/δ[1].

Synonyms	DG172 (dihydrochloride), DG-172 dihydrochloride
Molecular Weight	455.2
Formula	C20H22BrCl2N3
CAS No.	1361504-77-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 14.29 mg/mL (31.39 mM), Sonification is recommended.

References and Literature

1. Lieber S, et al. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J Med Chem. 2012 Mar 22;55(6):2858-68. 2. Yao PL, Chen L, Hess RA,et al.Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling.J Biol Chem. 2015 Sep 18;290(38):23416-31.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Anti-Hypertension Compound Library Transcription Factor-Targeted Compound Library DNA Damage & Repair Compound Library Anti-Breast Cancer Compound Library Lipid Metabolism Compound Library Covalent Inhibitor Library Glycometabolism Compound Library Anti-Diabetic Compound Library

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Keywords

DG172 dihydrochloride 1361504-77-9 DNA Damage/DNA Repair Metabolism PPAR DG 172 DG172 (dihydrochloride) DG172 DG-172 dihydrochloride inhibit DG 172 Dihydrochloride DG172 Dihydrochloride Inhibitor Peroxisome proliferator-activated receptors DG-172 Dihydrochloride DG-172 inhibitor

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