Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 310.00 | |
50 mg | In stock | $ 463.00 | |
100 mg | In stock | $ 679.00 | |
500 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 94.00 |
Description | DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
Targets&IC50 | DHODH:5.03(pKa) |
In vitro | A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure. |
Molecular Weight | 265.27 |
Formula | C15H11N3O2 |
CAS No. | 1263303-95-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (94.24 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DHODH-IN-11 1263303-95-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism DNA/RNA Synthesis Dehydrogenase antiinflammatory DHODH IN 11 Inhibitor Leflunomide Rat DHODHIN11 cyano-oximes Dihydroorotate Dehydrogenase inhibit DHODH inhibitor