Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK. |
In vitro | DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally[1]. |
In vivo | DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally[1]. |
Molecular Weight | 407.7 |
Formula | C16H8ClF6N3O |
CAS No. | 2102672-22-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (196.22 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DK419 2102672-22-8 Chromatin/Epigenetic Cytoskeletal Signaling PI3K/Akt/mTOR signaling Stem Cells Wnt/beta-catenin AMPK inhibit Wnt β-catenin DK-419 Inhibitor Beta catenin DK 419 inhibitor