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DR2313

Catalog No. T22749   CAS 284028-90-6
Synonyms: DR 2313

DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.

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DR2313 Chemical Structure
DR2313, CAS 284028-90-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 50.00
10 mg In stock $ 83.00
25 mg In stock $ 165.00
50 mg In stock $ 247.00
100 mg In stock $ 367.00
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Purity: 99.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
Targets&IC50 PARP2:0.24 μM, PARP1:0.20 μM
In vitro DR 2313 decreases neuronal cell death in models of cerebral ischemia in vivo and in vitro.
In vivo In both permanent and transient focal ischemia models in rats, pretreatment with DR2313 (10 mg/kg i.v. bolus and 10 mg/kg/h i.v. infusion for 6 h) significantly reduced the cortical infarct volume.?To determine the therapeutic time window of neuroprotection by DR2313, the effect of post-treatment was examined in transient focal ischemia model and compared with that of a free radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolone-5-one).?Pretreatment with MCI-186 (3 mg/kg i.v. bolus and 3 mg/kg/h i.v. infusion for 6 h) significantly reduced the infarct volume, whereas the post-treatment failed to show any effects.?In contrast, post-treatment with DR2313 (same regimen) delaying for 2 h after ischemia still prevented the progression of infarction.?These results indicate that DR2313 exerts neuroprotective effects via its potent PARP inhibition, even when the treatment is initiated after ischemia.?Thus, a PARP inhibitor like DR2313 may be more useful in treating acute stroke than a free radical scavenger[1].
Synonyms DR 2313
Molecular Weight 182.24
Formula C8H10N2OS
CAS No. 284028-90-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.3mg/mL

H2O: 9.1mg/mL

TargetMolReferences and Literature

1. Nakajima H, et, al. A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J Pharmacol Exp Ther. 2005 Feb;312(2):472-81.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Prostate Cancer Compound Library Bioactive Compound Library Anti-Pancreatic Cancer Compound Library DNA Damage & Repair Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-Ovarian Cancer Compound Library NO PAINS Compound Library

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Keywords

DR2313 284028-90-6 Chromatin/Epigenetic DNA Damage/DNA Repair PARP polymerase inhibit neuroprotective poly(ADP-ribose) DR-2313 poly ADP ribose polymerase ischemic Inhibitor DR 2313 inhibitor

 

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