Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 83.00 | |
25 mg | In stock | $ 165.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 367.00 |
Description | DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective. |
Targets&IC50 | PARP2:0.24 μM, PARP1:0.20 μM |
In vitro | DR 2313 decreases neuronal cell death in models of cerebral ischemia in vivo and in vitro. |
In vivo | In both permanent and transient focal ischemia models in rats, pretreatment with DR2313 (10 mg/kg i.v. bolus and 10 mg/kg/h i.v. infusion for 6 h) significantly reduced the cortical infarct volume.?To determine the therapeutic time window of neuroprotection by DR2313, the effect of post-treatment was examined in transient focal ischemia model and compared with that of a free radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolone-5-one).?Pretreatment with MCI-186 (3 mg/kg i.v. bolus and 3 mg/kg/h i.v. infusion for 6 h) significantly reduced the infarct volume, whereas the post-treatment failed to show any effects.?In contrast, post-treatment with DR2313 (same regimen) delaying for 2 h after ischemia still prevented the progression of infarction.?These results indicate that DR2313 exerts neuroprotective effects via its potent PARP inhibition, even when the treatment is initiated after ischemia.?Thus, a PARP inhibitor like DR2313 may be more useful in treating acute stroke than a free radical scavenger[1]. |
Synonyms | DR 2313 |
Molecular Weight | 182.24 |
Formula | C8H10N2OS |
CAS No. | 284028-90-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.3mg/mL
H2O: 9.1mg/mL
You can also refer to dose conversion for different animals. More
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DR2313 284028-90-6 Chromatin/Epigenetic DNA Damage/DNA Repair PARP polymerase inhibit neuroprotective poly(ADP-ribose) DR-2313 poly ADP ribose polymerase ischemic Inhibitor DR 2313 inhibitor