Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 329.00 | |
5 mg | In stock | $ 798.00 | |
10 mg | In stock | $ 1,090.00 | |
25 mg | In stock | $ 1,650.00 | |
50 mg | In stock | $ 2,230.00 | |
100 mg | In stock | $ 2,930.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 931.00 |
Description | DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax. |
In vivo | DSM421, a dihydroorotate dehydrogenase inhibitor, was in preclinical development as a potential treatment option for malaria. When tested in a core battery of safety pharmacology assays, DSM421 did not produce any effects at oral doses up to 750 mg/kg in an Irwin test in rats, but a respiratory study in rats using head-out plethysmography resulted in substantial changes in respiratory function as well as moribundity and mortality at that and lower doses.[1] |
Synonyms | DSM 421, DSM-421 |
Molecular Weight | 358.27 |
Formula | C14H11F5N6 |
CAS No. | 2011769-21-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (27.91 mM)
You can also refer to dose conversion for different animals. More
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DSM421 2011769-21-2 Metabolism Dehydrogenase DSM 421 DSM-421 inhibitor inhibit