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Deoxyelephantopin

Catalog No. TN1079 CAS 29307-03-7

Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling

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Deoxyelephantopin, CAS 29307-03-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 368.00
25 mg	In stock	$ 596.00
50 mg	In stock	$ 863.00
1 mL * 10 mM (in DMSO)	In stock	$ 253.00

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Purity: 99.69%

Purity: 99.6%

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Description	Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling
In vitro	Deoxyelephantopin was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4, and protein expression and resultant enzymatic activity. The mRNA and protein expression of cytochrome isoforms were carried out using an optimized multiplex qRT-PCR assay and Western blot analysis, respectively. Human CYP3A4 protein expression was determined using an optimized hCYP3A4-HepG2 cell-based assay and the enzymatic activity was evaluated using P450-Glo CYP3A4 assay. The molecular interaction and possible inhibition of Deoxyelephantopin of the CYP3A4 enzyme was determined in silico and further validated using substrate-specific CYP3A4 inhibition assays. Deoxyelephantopin produced no significant effect on the CYP1A2 and CYP2D6 mRNA and protein expression. However, it has a weak induction effect on CYP3A4 at the transcriptional level[1]
Source	Natural Products > Asteraceae > Elephantopus

Molecular Weight	344.36
Formula	C19H20O6
CAS No.	29307-03-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.44 mg/mL (10 mM)

References and Literature

1. Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.Food Chem Toxicol. 2013 Oct;60:98-108.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Pyroptosis Compound Library Anti-Cancer Compound Library Antidepressant Compound Library Bioactive Compounds Library Max Anti-Prostate Cancer Compound Library Natural Product Library Selected Plant-Sourced Compound Library Immunology/Inflammation Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Keywords

Deoxyelephantopin 29307-03-7 NF-Κb NF-κB Akt Inhibitor β-catenin MAPK Nuclear factor-κB PI3K Nuclear factor-kappaB anticancer inhibit inhibitor

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