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Doxycycline monohydrate

Catalog No. T8259 CAS 17086-28-1

Synonyms: 水合强力霉素, 强力霉素一水物

Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)

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Doxycycline monohydrate, CAS 17086-28-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Doxycycline monohydrate is an inhibitor of metalloproteinase (MMP)
In vivo	Doxycycline treatment inhibits the activity of tissue MMP and attenuates the decrease in the collagen content in aortas of mice haploinsufficient for collagen III, as well as prevents the development of stress-induced vessel pathology.?Doxycycline merits clinical testing as a treatment for vEDS[1].

Synonyms	水合强力霉素, 强力霉素一水物
Molecular Weight	462.455
Formula	C22H26N2O9
CAS No.	17086-28-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 47 mg/mL (11.63 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Briest W , Cooper T K , Tae H J , et al. Doxycycline Ameliorates the Susceptibility to Aortic Lesions in a Mouse Model for the Vascular Type of Ehlers-Danlos Syndrome[J]. Journal of Pharmacology & Experimental Therapeutics, 2011, 337(3):621-627. 2. Trajano V C C , Costa K J R , Lanza C R M , et al. Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate PCL and PLGA composite[J]. Materials science & engineering, 2016, 64(jul.):370-375.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Doxycycline monohydrate 17086-28-1 蛋白酶体微生物学 Antibacterial Antibiotic MMP Parasite inhibit Doxycycline Inhibitor Matrix metalloproteinases Bacterial inhibitor

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