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Doxylamine succinate

Catalog No. T1115 CAS 562-10-7

Synonyms: Decapryn

Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of the gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.

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Doxylamine succinate, CAS 562-10-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 37.00
50 mg	In stock	$ 50.00
100 mg	In stock	$ 61.00
200 mg	In stock	$ 102.00
500 mg	In stock	$ 167.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

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Description

In vitro

In B6C3F1 mice, the impact of Doxylamine on microsomal enzyme activity and serum thyroid hormone levels was investigated by administering Doxylamine succinate for 7 or 15 days with dietary incorporation at levels of 0, 40, 375, 750, or 1500 ppm, corresponding to the free base form of Doxylamine. Findings reveal that Doxylamine acts as an inducer of hepatic microsomal cytochrome P450 enzymes, consistent with the hypothesis that Doxylamine increases liver enzyme activities involved in T4 metabolism in B6C3F1 mice.

Synonyms	Decapryn
Molecular Weight	388.46
Formula	C21H28N2O5
CAS No.	562-10-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (257.43 mM)

H2O: 100 mg/mL (257.43 mM)

References and Literature

1. Bookstaff RC, et al. Toxicol Appl Pharmacol, 1996, 141(2), 584-594. 2. Ge S, Wang X, Hou Y, et al. Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2[J]. European Journal of Pharmacology. 2021: 173897.

Citations

1. Ge S, Wang X, Hou Y, et al. Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2. European Journal of Pharmacology. 2021 Apr 5;896:173897. doi: 10.1016/j.ejphar.2021.173897. Epub 2021 Jan 23.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library GPCR Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Inhibitor Library Neuronal Signaling Compound Library Carboxylic Acid Fragment Library With Solubility Clinical Compound Library Anti-Obesity Compound Library

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Keywords

Doxylamine succinate 562-10-7 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor B6C3F1 mice Low toxicity Liver inhibit Subcutaneous infiltration Doxylamine Succinate Inhibitor Decapryn Local analgesic Doxylamine inhibitor

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