Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 243.00 | |
10 mg | In stock | $ 396.00 | |
25 mg | In stock | $ 676.00 | |
50 mg | In stock | $ 962.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,590.00 |
Description | EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor. |
Targets&IC50 | EGFR:0.218 nM, EGFR (WT):7.92 nM |
In vitro | TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib. It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively. |
Synonyms | TQB3804 |
Molecular Weight | 694.6 |
Formula | C32H41BrN9O2P |
CAS No. | 2267329-76-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
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EGFR-IN-7 2267329-76-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER1 EGFR IN 7 ErbB-1 Inhibitor inhibit Epidermal growth factor receptor TQB 3804 TQB-3804 EGFRIN7 TQB3804 inhibitor