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EOC317

Catalog No. T4318 CAS 939805-30-8

Synonyms: ACTB-1003, ACTB1003, ACTB 1003

EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

EOC317, CAS 939805-30-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 93.00
2 mg	In stock	$ 137.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 347.00
25 mg	In stock	$ 589.00
50 mg	In stock	$ 842.00
100 mg	In stock	$ 1,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 268.00

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Purity: 99.26%

Purity: 99%

Purity: 98.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).
Targets&IC50	FGFR1:6 nM, Tie2:4 nM, VEGFR2:2 nM
In vitro	ACTB-1003 targets cancer mutations via FGFR inhibition FGFR1 (IC50: 6 nM), angiogenesis through inhibition of VEGFR2 (2 nM) and Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). In cell lines with FGFR genetic alterations - OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1, ACTB-1003 can markedly and dose-dependently inhibit tumor growth. OPM2 cells harbor the FGFR3 t (4:14) translocation, FGFR3 K650E mutation and PTEN deletion while the Ba/F3-TEL-FGFR1 cells are driven by FGFR1 over-expression.
In vivo	ACTB-1003 inhibit tumor angiogenesis evident by the inhibition of CD31 staining in tumor sections. The combination ACTB-1003 with 5-FU or paclitaxel not diminish the activity or increasing the toxicity of these chemotherapy agents in the HCT-116 colon tumor xenograft model.

Synonyms	ACTB-1003, ACTB1003, ACTB 1003
Molecular Weight	591.53
Formula	C27H26F5N7O3
CAS No.	939805-30-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35 mg/mL

References and Literature

1. Patel K, et al. ACTB-1003: An oral kinase inhibitor targeting cancer mutations (FGFR), angiogenesis (VEGFR2, TEK), and induction of apoptosis (RSK and p70S6K). Journal of Clinicalal Oncology 28, no. 15 DOI: 10.1200/jco.2010.28.15_suppl.e13665

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Inhibitor Library Drug Repurposing Compound Library Tyrosine Kinase Inhibitor Library Covalent Inhibitor Library NO PAINS Compound Library Bioactive Compound Library

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CYC-116 PTC299 NVP-ACC789 MMPP Pz-1 BIBF 1202 PF-03814735 PHA-665752

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EOC317 939805-30-8 Angiogenesis Tyrosine Kinase/Adaptors VEGFR Tie-2 FGFR EOC-317 Fibroblast growth factor receptor Vascular endothelial growth factor receptor inhibit Inhibitor ACTB-1003 EOC 317 ACTB1003 ACTB 1003 inhibitor

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